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Esser extent in ZR-75 and EFM-19. The reduction of Akt phosphorylation led to a reduction in phosphorylation of its downstream target, Bad, in MCF-7 and EFM-19. Reduced phosphorylation of Bad promotes cell death because unphosphorylated Bad sequesters anti-apoptotic Bcl family proteins which prevents their inhibition of pro-apoptotic proteins Bax and Bak. In contrast to Akt phosphorylation, phosp
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Five of the 15 patients died, 7 of 15 were still alive, and the current status of 3 of 15 patients was unknown. Diseases were heterogeneous. Six of the 15 parents refused treatment for their children initially, 8 of 15 discontinued during the course of treatment. Five patients were treated after parental custody had been withdrawn due to the lack of compliance. All these five patients survived. P
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