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Esser extent in ZR-75 and EFM-19. The reduction of Akt phosphorylation led to a reduction in phosphorylation of its downstream target, Bad, in MCF-7 and EFM-19. Reduced phosphorylation of Bad promotes cell death because unphosphorylated Bad sequesters anti-apoptotic Bcl family proteins which prevents their inhibition of pro-apoptotic proteins Bax and Bak. In contrast to Akt phosphorylation, phosph

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