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R-activated receptor alpha (PPARa) regulates CYP4A [11-14]. SXR and CAR are closely related nuclear receptors (NR1I) that are activated by a wide range of compounds including several clinically used drugs [15]. AhR is a major xenobioticsensing receptor that is activated by environmental pollutants such as dioxin and PAHs including benzo[a]pyrene (BaP) [16,17]. AhR and its dimerization partner AhR

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